Evaluation of early myocardial damage in systemic sclerosis (SSc): a cardiovascular magnetic resonance study
نویسندگان
چکیده
Background Cardiac involvement in systemic sclerosis (SSc) is mainly characterised by diffuse myocardial fibrosis and impairment of the microcirculation; even if clinically silent, it is increasingly recognized to be responsible for higher morbidity and mortality rate. Cardiovascular magnetic resonance (CMR) is the most accurate non-invasive method able to detect myocardial inflammation and fibrosis, even though traditional CMR techniques such as T2-weighted and late gadolinium enhancement (LGE) are inaccurate to assess diffuse myocardial disease. Our aim was to investigate diffuse cardiac damage and perfusion abnormalities in asymptomatic SSc patients without known cardiac disease, using newer non-invasive imaging technique, such as T1 mapping and extracellular volume fraction (ECV), in pre-clinical stage.
منابع مشابه
Early markers of heart damage in systemic sclerosis: role of cardiac magnetic resonance with late gadolinium enhancement
Background Cardiovascular complications are one of the main causes of death in patients affected by systemic sclerosis (SSc). Heart involvement is characterized by myocardial fibrosis, arrhythmias, conduction system defects and pericardial inflammation. Also patients with subclinical cardiac involvement have a poor prognosis: thus early markers of heart damage are necessary to identify patients...
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