Evaluation of early myocardial damage in systemic sclerosis (SSc): a cardiovascular magnetic resonance study

نویسندگان

  • Nicola Galea
  • Marco Francone
  • Giovanni Barchetti
  • Amelia C Trombetta
  • Edoardo Rosato
  • Iacopo Carbone
چکیده

Background Cardiac involvement in systemic sclerosis (SSc) is mainly characterised by diffuse myocardial fibrosis and impairment of the microcirculation; even if clinically silent, it is increasingly recognized to be responsible for higher morbidity and mortality rate. Cardiovascular magnetic resonance (CMR) is the most accurate non-invasive method able to detect myocardial inflammation and fibrosis, even though traditional CMR techniques such as T2-weighted and late gadolinium enhancement (LGE) are inaccurate to assess diffuse myocardial disease. Our aim was to investigate diffuse cardiac damage and perfusion abnormalities in asymptomatic SSc patients without known cardiac disease, using newer non-invasive imaging technique, such as T1 mapping and extracellular volume fraction (ECV), in pre-clinical stage.

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عنوان ژورنال:

دوره 17  شماره 

صفحات  -

تاریخ انتشار 2015